알파칼시돌과 오스테오트리올은 모두 비타민 D라고 할 수 있습니다. 그들은 비타민 D의 다른 대사 형태이며 둘 다 칼슘 흡수를 촉진합니다. 비타민 D와 알파 오스테오트리올은 결국 체내에서 오스테오트리올로 대사됩니다.
Vitamin D3 is not biologically active and needs to be hydroxylated twice before it becomes biologically active. First, vitamin D3 is transported to the liver after binding to vitamin D-binding proteins in the blood. In the liver, it is transformed into 25-hydroxyvitamin D3 [25-(OH)-D3] catalyzed by 25-hydroxylase; after entering the circulation, it is also bound to vitamin D binding proteins and subsequently transported to the kidneys, where it is catalyzed by renal 1α-hydroxylase to produce the hormonally active metabolite 1,25-dihydroxyvitamin D3 [1,25-(OH)2-D3], which is the active vitamin D3, also known as osteotriol or calcitriol in Chemicalbook.
After entering the bloodstream, osteotriol also binds to vitamin D-binding proteins and reaches various tissues and organs, such as the small intestine, bones and kidneys, where it binds to the vitamin D receptors in the tissue cells and exerts its biological effects. Alfacalcitol [1α-(OH)-D3] is a product of the direct activation of vitamin D3 by 1α-hydroxylase in the kidney and is present in very small amounts in the body. Both osteotriol and alfacalcidol can be synthesised artificially. They can be used as medicines but are not usually supplemented as nutrients.
사용
비타민D3유방암, 결장암 및 전립선암에 항증식 및 항전이 효과가 있는 정상 세포 및 암세포의 증식 및 분화를 조절하는 리간드 의존성 전사 인자 계열의 일원인 수용체를 통해 작용합니다. 장과 뼈에 있는 활성화된 비타민D 수용체는 또한 칼슘 흡수와 항상성을 유지합니다.
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